D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients (NCT07590362) | Clinical Trial Compass
RecruitingNot Applicable
D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients
Egypt100 participantsStarted 2026-04-15
Plain-language summary
This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success from invasive mechanical ventilation in COPD patients. Diaphragmatic ultrasound measurements will be performed during spontaneous breathing trials, and patients will be followed for 72 hours after extubation to assess weaning outcomes.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria.
* Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial.
* Hemodynamically stable without significant vasopressor support.
* Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O .
* Preserved mental status and ability to initiate spontaneous breathing.
* Successful tolerance of spontaneous breathing trial conducted on CPAP mode with pressure support ≤ 8 cmH2O.
Exclusion Criteria:
* Refusal of consent
* Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis.
* Large pneumothorax or pathology interfering with ultrasound assessment.
* Terminal extubation.
* Recent major thoracic surgery.
* Poor sonographic window despite repeated attempts.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
AUROC of D-RSBI for prediction of successful weaning