Robot-Assisted Gait Training vs NMES in Parkinson's Disease (NCT07589296) | Clinical Trial Compass
RecruitingNot Applicable
Robot-Assisted Gait Training vs NMES in Parkinson's Disease
Turkey (Türkiye)40 participantsStarted 2026-04-15
Plain-language summary
This prospective, randomized, assessor-blinded clinical trial aims to compare the effects of robot-assisted gait training and quadriceps neuromuscular electrical stimulation (NMES) when added to a standard exercise rehabilitation program in patients with Parkinson disease.
Participants will be randomly assigned to two parallel groups. Both groups will receive a standard rehabilitation program, while one group will additionally undergo robot-assisted gait training and the other group will receive quadriceps NMES. The interventions will be administered five days per week for six weeks.
Clinical outcomes, including balance, functional mobility, gait performance, and disease severity, will be evaluated at baseline, post-treatment, and follow-up (week 14). In addition, ultrasound-based assessments of quadriceps muscle thickness and cross-sectional area will be performed to investigate muscle adaptations.
The results of this study are expected to provide comparative evidence regarding the effectiveness of these two rehabilitation approaches and contribute to optimizing rehabilitation strategies in Parkinson disease.
Who can participate
Age range
40 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of Parkinson's disease according to established clinical criteria
* Age between 40 and 80 years
* Hoehn and Yahr stage II-III
* Ability to walk independently with or without assistive devices
* Stable medical treatment for at least 4 weeks prior to study enrollment
* Ability to understand and follow instructions
* Willingness to participate and provide written informed consent
Exclusion Criteria:
* Severe cognitive impairment or inability to follow instructions
* Hoehn and Yahr stage IV-V Parkinson's disease
* Severe musculoskeletal disorders affecting gait (e.g., advanced osteoarthritis, recent fracture)
* History of lower extremity surgery within the last 6 months
* Severe cardiovascular or respiratory disease limiting exercise participation
* Presence of other neurological disorders affecting mobility (e.g., stroke, multiple sclerosis)
* Contraindications to electrical stimulation (e.g., pacemaker, implanted electronic devices)
* Skin lesions or infections at electrode placement sites
* Participation in another structured rehabilitation program within the last 3 months
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Timed Up and Go Test (TUG)
Timeframe: Baseline, 6 weeks, and 14 weeks
Trial details
NCT IDNCT07589296
SponsorKanuni Sultan Suleyman Training and Research Hospital