CLIME-CJD: A Multimodal Study (NCT07589283) | Clinical Trial Compass
By InvitationNot Applicable
CLIME-CJD: A Multimodal Study
China150 participantsStarted 2022-01-01
Plain-language summary
Creutzfeldt-Jakob disease (CJD) is a rare and rapidly progressive neurological disorder. This study aims to describe and summarize the key features of CJD by looking back at medical records of patients who were diagnosed with CJD at our hospital. The researchers will collect information from routine clinical evaluations, including patients' symptoms, blood tests, cerebrospinal fluid analysis, brain imaging (such as MRI and PET), and electroencephalography (EEG). By analyzing these data together, the study hopes to provide a clearer picture of how CJD presents in routine clinical practice. This may help doctors recognize the disease more quickly in the future. No new tests or treatments will be given to patients. All data are collected from existing medical records.
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of definite or probable Creutzfeldt-Jakob Disease (CJD) according to the established WHO diagnostic criteria
* Available medical records covering at least one of the following: clinical history, peripheral blood test results, cerebrospinal fluid (CSF) analysis findings, brain MRI reports/images, or EEG reports
* Hospitalized or evaluated at the participating institution during the study period
Exclusion Criteria:
* Alternative diagnosis confirmed that explains all clinical features (e.g., autoimmune encephalitis, rapidly progressive dementia due to other causes)
* Incomplete medical records with no relevant clinical, laboratory, imaging, or EEG data available
* Patient or legal representative declined the use of medical records for research purposes (where applicable according to local regulations)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial is enrolling by invitation only, can you tell me whether I or my family member might be considered for an invitation, and what criteria are typically used to select participants?
2This study seems focused on collecting diagnostic data rather than testing a treatment — does that mean participating wouldn't change my current care plan, and what would actually be asked of me or my loved one as part of the study?
3The trial is measuring how often CJD patients show characteristic diagnostic findings — could the tests or assessments involved in this study give us any additional information about the diagnosis that we wouldn't otherwise get through standard care?
4Since this is listed as Phase NA, which often means it's an observational or diagnostic study rather than a treatment trial, should I also be asking about separate treatment options or clinical trials that are testing actual therapies for CJD or prion disease?
5Given how rare and rapidly progressing CJD can be, are there any time-sensitive factors that would affect whether participation in this study is even feasible for our situation, and how quickly would we need to make a decision?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of CJD Patients With Characteristic Diagnostic Findings
Timeframe: Baseline
Trial details
NCT IDNCT07589283
SponsorFirst Affiliated Hospital of Fujian Medical University