AI-GF-GNW on Prolonged Grief Reactions (NCT07589088) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
AI-GF-GNW on Prolonged Grief Reactions
China126 participantsStarted 2026-05-25
Plain-language summary
Prolonged Grief Disorder (PGD) is a severe, disabling condition characterized by intense yearning and difficulty accepting the reality of loss, which significantly impairs the academic and psychosocial functioning of bereaved adolescents. While Grief-Focused Cognitive Behavioral Therapy (GF-CBT) is effective, its high cost and resource-intensive nature limit its accessibility for adolescents in mainland China. Grief-Focused Guided Narrative Writing (GF-GNW) offers a scalable, low-cost alternative that facilitates memory integration.
Furthermore, integrating Artificial Intelligence (AI) to provide personalized, structured feedback has the potential to simulate therapist functions and enhance intervention efficacy. However, the specific efficacy of AI-assisted feedback in this context remains empirically unvalidated.
This parallel randomized controlled trial aims to examine the effectiveness of AI-assisted GF-GNW (AI-GF-GNW) in treating Chinese adolescents (aged 10-19) with subclinical PGD, compared to a no-feedback NF-GF-GNW group and a free writing group. Primary outcomes include PGD symptom severity, while secondary outcomes assess depression, anxiety, and daily functioning. We hypothesize that both active intervention arms will significantly alleviate PGD and related symptoms compared to the free writing group, and that the AI-GF-GNW group will demonstrate a significantly greater reduction in symptoms and functional impairment than the NF-GF-GNW group.
Who can participate
Age range
10 Years – 19 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Junior and senior high school students currently studying in Chinese Mainland, aged 10-19;
* Between 6 and 60 months prior to the experimental period, experienced the death of a significant family member or close friend or close friend;
* The total symptom score of PG-13-R is between 20-29 points;
* Ability to write and understand written guidelines, to use the mobile phone to interact with AI;
* Consent to participate in the study.
Exclusion Criteria:
* Diagnosed or previously diagnosed with mental illness
* The bereavement time does not meet the time window
* PG-13-R score is not within the range
* At present, there is suicidal ideation or recent severe self harm behavior (Reynolds' Suicidal Ideation Questionnaire, SIQ-JR-4\>0), and a crisis intervention hotline is provided when necessary.
* Has received other grief counseling or is currently taking psychiatric medication within the past month
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses an AI-based intervention for prolonged grief — can you help me understand what that actually means in practice, and whether an AI tool is an appropriate option given where I am in my grief or depression right now?
2The trial is listed as 'not yet recruiting' — do you know when it's expected to open, and does it make sense for me to wait for it versus starting a more established treatment for prolonged grief or major depression now?
3The study is measuring my grief symptoms using the PG-13-R scale and my depression using the PHQ-9 — based on my current scores or symptoms, do you think I would likely meet the kind of profile this trial is looking for?
4Since this trial is listed as Phase NA, which often applies to behavioral or tech-based interventions rather than drug trials, what is currently known about the safety and effectiveness of AI-guided grief support, and are there any risks I should be aware of before considering it?
5The trial includes people with disabilities as a study population — if I have a physical or cognitive disability, how might that affect my ability to participate, and is there anything about how the AI tool works that we should think through together given my specific situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.