CompletedNot Applicable

Ultrasound-guided Transgluteal Sciatic Nerve Hydrodissection for the Treatment of Sciatica in the Emergency Department

United States69 participantsStarted 2024-01-12

Plain-language summary

The goal of this observational study is to see whether it would be feasible to treat patients who come to the emergency department with pain related to sciatica using an ultrasound guided injection of dextrose in water solution ("sugar water") into the tissue that surrounds the sciatic nerve in the gluteal region. THe study will looks at a few things: * Is the treatment feasible within the setting of the emergency department * Is the treatment safe in the short term (up to 72 hours after the injection) * Is the treatment good for lowering patients' pain from sciatica in the short term (immediate and up to 72 hours' follow up) * How does the treatment compare to current standard medicines given to patients for sciatica in the emergency department in terms of lowering pain Patients who came to the emergency department and had the injection as part of their care for sciatica will answer some questions about their symptoms during a phone call follow up 72 hours after leaving the emergency department.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 years or older * Clinically diagnosed acute sciatica, defined as pain and/or paresthesias in a -sciatic nerve distribution * Willing to undergo the injection procedure * Verbal informed consent provided prior to enrollment * Adequate sonographic visualization of the sciatic nerve in the transgluteal window confirmed on screening ultrasound Exclusion Criteria: * Fever or signs of systemic infection * Suspected spinal infection * Suspected spinal malignancy * Signs or symptoms of cauda equina syndrome * Acute traumatic mechanism of pain * Localized infection or skin breakdown at the proposed injection site * Known allergy to study injectate (5% dextrose in water) or procedural materials * Refusal to participate * Inability to adequately visualize the target anatomy on ultrasound for safe injection

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Rate of Successful Transgluteal Sciatic Nerve Hydrodissection (TSNH) Procedure Completion Among Eligible Emergency Department Patients

Timeframe: From enrollment to 72-hour follow-up completion

Incidence of Procedure-Related Adverse Events Within 72 Hours Following Transgluteal Sciatic Nerve Hydrodissection (TSNH)

Timeframe: From time of injection to 72-hour post-discharge telephone follow-up

Trial details

NCT IDNCT07588126

SponsorKaiser Permanente

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-21

View on ClinicalTrials.gov More Sciatica Acute trials