Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast… (NCT07587957) | Clinical Trial Compass
RecruitingNot Applicable
Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors
United States40 participantsStarted 2026-01-07
Plain-language summary
The purpose of this study is to assess the feasibility of a 4-week intervention combining exercise and transcranial alternating current stimulation (Ex+tACS) in breast cancer survivors who report experiencing cancer-related cognitive impairment. Feasibility will be assessed by measuring participant retention, adherence, satisfaction with the intervention, and safety. The researchers will also examine pre-to-post intervention changes in attention, executive function, working memory, perceived cognitive function, and physical function before, after, and four weeks post intervention completion in the Ex+tACS group compared to a control group who will receive exercise and a placebo tACS condition (CON).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Breast cancer survivors (≥18 years) will be eligible to participate if the following inclusion criteria is met:
* Diagnosed non-metastatic breast cancer (stages 0-3)
* Completed primary breast cancer treatment (surgery, chemotherapy, radiation) for at least 3 months
* Self-reported cognitive impairment after cancer treatment
Exclusion Criteria:
* Current participation in aerobic exercise for ≥60 min/wk
* Contraindication or impairment that precludes the potential participant from exercise as defined by the American College of Sports Medicine
* The presence of serious medical illnesses, metal implants, previous brain trauma, epilepsy or history of seizures, previous surgery to the head or spinal cord, or skin problems at the forehead area where the tACS electrodes will be applied
* Uncontrolled cardiovascular disease
* Functional impairments or physical condition that would make exercise unsafe
* Metastatic cancer or diagnosis of a different cancer (excluding melanoma) within the past 5 years
* Contraindication to exercise a defined by the American College of Sports Medicine
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Adherence
Timeframe: From baseline to the end of the 4-week intervention
2
Retention
Timeframe: From baseline to the end of the 4-week intervention
3
Acceptability
Timeframe: From baseline to the end of the 4-week intervention
4
Safety (Adverse Events)
Timeframe: From baseline to the end of the 4-week intervention