Natural Cervical Ripening to Prevent Pharmacological Induction of Labor - a Pilot Study. (NCT07587632) | Clinical Trial Compass
RecruitingNot Applicable
Natural Cervical Ripening to Prevent Pharmacological Induction of Labor - a Pilot Study.
Switzerland74 participantsStarted 2026-04-10
Plain-language summary
As of today, around 25% of all vaginal births happen after induction of labor (IOL). The internal guidelines of the University Hospital Zurich currently recommend pregnant women with a non-insulin dependent gestational diabetes an IOL around term. One possibility to prevent an IOL and increase the chance for a spontaneous onset of birth is a ripening of the cervix by alternative methods in an outpatient setting. The primary objective of this study is to evaluate the effect of natural cervical ripening methods on the time interval between 37 weeks (beginning of the intervention) and the onset of spontaneous labor.
Who can participate
Age range
18 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Singleton gestation
* Non-insulin dependent, dietetically managed gestational diabetes
* Greater than or equal to 34 weeks.
* Planned vaginal birth at the University Hospital of Zurich
* Planned IOL for 40 weeks of gestation.
* Communication in German and/or English language possible.
Exclusion Criteria:
* Pregnant women with multiple gestation
* Fetal macrosomia \>95th percentile
* Intrauterine growth restriction \<3rd percentile
* Already in labor (regular contractions or premature rupture of membranes (PROM)
* Patients scheduled for IOL before 40 weeks
* Insulin-dependent diabetes
* Planned cesarean section
* Planned birth in an external hospital
* Inability to follow the procedures e.g. due to language problems, psychological disorders
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
the time interval between 37/0 weeks of gestation and the onset of labor.
Timeframe: Between 37/0 weeks of gestation until the onset of labor