Granulation Tissue From Residual Periodontal Pockets
Italy21 participantsStarted 2026-05-07
Plain-language summary
This observational study aims to describe the histopathological features of granulation tissue (GT) found in residual periodontal pockets at the time of surgical intervention, after completion of the first two steps of periodontal therapy, according to EFP guidelines (Sanz et al., 2020).
A secondary objective was to analyze GT characteristics in relation to clinical outcomes (e.g., defect type, probing depth reduction and clinical attachment gain) in order to identify possible statistical associations between tissue patterns and clinical improvements.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-75 years
* Full Mouth Plaque Score (FMPS) \<15% at re-evaluation
* Full Mouth Bleeding Score (FMBS) \<15% at re-evaluation
* At least one site with probing depth (PPD) ≥5 mm after non-surgical therapy
* Written informed consent
* Good compliance throughout periodontal therapy
Exclusion Criteria:
* Pregnancy or breastfeeding
* Use of systemic or local antibiotics in the previous 3 months
* Smoking
* Use of anti-inflammatory or anticoagulant/antiplatelet drugs
* Systemic, cardiovascular, or infectious diseases affecting periodontal health
* Dental contraindications to surgery (fractures, untreated endodontic lesions, mobility \> grade 2, or faulty restorations)
* Non-compliant patients
* History of periodontal therapy in the previous year
* Ongoing orthodontic treatment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Histopathological characterization of granulation tissue components