Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children

Inclusion Criteria: * Age from 5 to \<15 years-old * Diagnosis of first episode of acute uncomplicated appendicitis confirming the diagnosis: * an increase in the calibre of the appendix, measured at more than 6 mm in diameter and non-compressibility * free fluid, echogenic fat, regional hyperemia * performed in hospital or reviewed by local radiologist investigators if performed outpatient. * Surgery expected within 24 hours after diagnosis * Parental good understanding of the monitoring French instructions * Free and informed consent, signed by both holders of parental authority/legal representative, with the accord of the minor patient. * Affiliation to the health insurance plan Exclusion Criteria: * Ultrasound or CT scan showing one or several stercoliths, a plastron, an abscess or peritonitis * Non-visualization of the appendix at ultrasound or CT scan * Situations contraindicating surgery or anesthesia (patient for whom surgery and anesthesia would pose a life-threatening risk) * Patients who have already received antibiotic therapy for acute appendicitis * Known immunodepression, ongoing immunosuppressive treatment, diabetes * Severe hematologic disorders (such as bone marrow failure, blood clotting disorders) * History of proved allergy to Penicillin * History of proved allergy to amoxicillin and/or clavulanic acid * History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or mono…