Not Yet RecruitingPhase 1/2

HAIC-TACE Plus Apatinib and Camrelizumab for Liver Cancer

315 participantsStarted 2026-06

Plain-language summary

To provide evidence-based medical evidence for the optimized combination strategy of local and systemic therapies.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Age 18-80 years.
. Diagnosed with hepatocellular carcinoma (HCC) in accordance with the Standardization for Diagnosis and Treatment of Primary Hepatic Carcinoma (2024 Edition) issued by the National Health Commission of the People's Republic of China.
. BCLC stage B or C, with no indication or refusal of surgical treatment, and measurable lesions meeting the mRECIST (Modified Response Evaluation Criteria in Solid Tumors) criteria on baseline imaging.
. Child-Pugh liver function grade A or well-compensated grade B (score ≤7).
. ECOG Performance Status (PS) score 0-1.
. Expected survival time ≥12 weeks.

Exclusion criteria

. Prior transarterial chemoembolization (TACE) or other local therapies for HCC (except bridging liver transplantation).
. Active viral hepatitis (hepatitis B or C) with pre-treatment viral load \>100 IU/mL (positive for HCV RNA or HBV DNA) or without consistent antiviral therapy.
. Alcohol abuse or pregnancy.
. Concurrent other malignancies or history of other malignancies within the past 3 years.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Progression-Free Survival (PFS) [Assessed by mRECIST Criteria]

Timeframe: Up to 27 months.

Trial details

NCT IDNCT07587034

SponsorShanghai Zhongshan Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-12

View on ClinicalTrials.gov More Liver Cancer trials