Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory. (NCT07585227) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory.
France50 participantsStarted 2026-05-06
Plain-language summary
The goal of this study is to investigate whether prospective memory, i.e., memory for delayed intentions, is impaired at moderate altitude (4,000m).
It will also allow to study the effect of air and oxygen administration during hypoxia exposure.
The main questions it aims to answer are:
* Does moderate acute hypoxia impair prospective memory ?
* If so, does air or oxygen adminsitration induce a restoration of prospective memory? Researchers will compare cognitive performance during normobaric hypoxia exposure to cognitive performance during normoxia (control situation).
Participants will:
* Session S0. Perform a battery of neuropsychological tests and questionnaires). EEG will be recorded during tests. A cheek swab will be performed.
* Sessions S1 and S2. Perform several cognitive tasks while exposed to hypoxia and to normoxia (2 different sessions, randomized order) in a normobaric chamber. These are standardized cognitive tests administered on a computer and cognitive tests embedded in a flight simulator scenario. Various questionnaires will be performed on a regular basis. Several physiological measurements will be performed continuously: EEG, ECG, SpO2 and breathing rate. Blood pressure will be measured at the beginning and at the end of hypoxia/normoxia exposure. A blood sample will also be performed. At last, participants will inhale air or oxygen through a mask while making a cognitive task in the chamber.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy volunteer
* Has provided informed consent
Exclusion Criteria:
* Individuals who do not understand French
* Pregnant or breastfeeding women
* Cardiovascular risk factor
* Infectious disease within the last 4 weeks
* Chronic cardiovascular, respiratory, hematological, neurological, psychiatric, or metabolic disease
* History of epileptic seizures, convulsions, or loss of consciousness
* Individuals with migraines
* History of a bleeding disorder
* History of high blood pressure
* Current medication use (excluding contraception)
* History of episodes of altitude intolerance
* Stay at high altitude (\> 3,500 m) within the last 3 months
* Anxiety score on the Hospital Anxiety and Depression (HAD) scale \> 7
* Depression score on the HAD scale \> 7
* Uncontrollable claustrophobia or a history of panic attacks
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in event-based prospective memory accuracy between hypoxia and normoxia conditions
Timeframe: Through study completion, an average of 1 month
Trial details
NCT IDNCT07585227
SponsorDirection Centrale du Service de Santé des Armées