Effect of High-Intensity Laser Therapy on Femoral Cartilage in Knee Osteoarthritis (NCT07584603) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect of High-Intensity Laser Therapy on Femoral Cartilage in Knee Osteoarthritis
Pakistan58 participantsStarted 2026-07-01
Plain-language summary
This clinical trial will evaluate the effects of High-Intensity Laser Therapy (HILT) on femoral cartilage thickness and other clinical outcomes in people with knee osteoarthritis. Participants aged 40 to 60 years with grade II or III knee osteoarthritis will be randomly assigned to receive either HILT plus conventional physiotherapy or conventional physiotherapy alone. Both groups will receive 12 treatment sessions on alternate days for 4 weeks. The study will assess changes in cartilage thickness using ultrasound, as well as improvements in pain, knee movement, muscle strength, and daily function. Findings from this research may help improve physiotherapy treatment strategies for patients with knee osteoarthritis.
Who can participate
Age range
40 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male and female participants aged 40-60 years.
* Diagnosed with knee osteoarthritis (Kellgren-Lawrence grade II or III).
* Knee pain for at least 3 months.
* Visual Analogue Scale (VAS) score ≥ 3.
* Willing to provide written informed consent and comply with treatment and follow-up schedule.
Exclusion Criteria:
* History of knee surgery or traumatic knee injury.
* Inflammatory arthritis (e.g., gout, psoriatic arthritis).
* History of cancer or psychiatric illness.
* Cognitive disorders (e.g., Parkinson's disease, Alzheimer's disease).
* Severe comorbidities limiting exercise (e.g., severe COPD, heart failure, cerebrovascular event).
* Hip or ankle joint disability.
* Intra-articular knee injection within the past 3 months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.