AI-Driven Metabolic Cohort in Overweight/Obese Chinese Adults (NCT07584330) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
AI-Driven Metabolic Cohort in Overweight/Obese Chinese Adults
2,800 participantsStarted 2026-05-01
Plain-language summary
The goal of this observational cohort study is to delineate the five-year dynamic trajectories of metabolic phenotypes in Chinese adults with overweight or obesity, with or without type 2 diabetes, focusing on transition rates from metabolically healthy overweight/obesity to unhealthy overweight/obesity or to type 2 diabetes, as well as the incidence and progression of diabetic complications and cardiovascular events in those with type 2 diabetes and overweight/obesity. Researchers will compare three phenotype groups, namely metabolically healthy overweight/obesity, metabolically unhealthy overweight/obesity, and type 2 diabetes with overweight/obesity, to assess differences in metabolic parameter changes, complication rates, and cardiovascular risk. Participants will use a digital health management platform for data upload and lifestyle support, and will complete comprehensive health assessments at baseline, at 2.5 years, and at 5 years, along with annual light follow-ups.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
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Inclusion criteria
. Able to understand and voluntarily sign the informed consent form, and willing to comply with all study requirements.
. Age between 18 and 60 years (inclusive).
. Meets at least one of the following overweight/obesity criteria: a) BMI ≥ 24 kg/m²; b) male waist circumference ≥ 90 cm, female waist circumference ≥ 85 cm.
. Capable of basic smartphone operation and able to use WeChat or similar communication tools for daily communication.
Exclusion criteria
. Diagnosis of type 1 diabetes, latent autoimmune diabetes in adults (LADA), maturity-onset diabetes of the young (MODY), or other specific types of diabetes.
. Endocrine or metabolic diseases that may affect body weight, including untreated thyroid disorders (hyperthyroidism: TSH \< 0.1 mIU/L with FT4 \> upper normal limit; hypothyroidism: TSH \> 10 mIU/L), Cushing syndrome, acromegaly, polycystic ovary syndrome, or hypopituitarism.