A Novel Two-Tooth Clip for ESD and EFTR of GIST: A Prospective RCT

Inclusion Criteria: Age ≥ 18 and ≤ 85 years. Patients diagnosed with gastric gastrointestinal lesions clinically indicated for ESD or EFTR. Lesion size between 2 cm and 5 cm in diameter. Willing and able to provide written informed consent. Exclusion Criteria: Lesions with clear evidence of deep submucosal invasion or distant metastasis precluding curative endoscopic resection. Severe coagulation dysfunction (international normalized ratio \>2.0, platelet count \<50,000/µL) or ongoing use of dual antiplatelet therapy/anticoagulants that cannot be appropriately bridged or discontinued per guidelines. Severe organ failure (cardiac, renal, hepatic, or respiratory) rendering the patient unsuitable for prolonged sedation or general anesthesia. Pregnancy or lactation. Prior surgical or endoscopic intervention at the target lesion site that results in significant fibrosis.