Effect of Semaglutide on Healing of Foot Ulcers in Type 2 Diabetes Patients

Inclusion Criteria: * Diagnosis of type 2 diabetes mellitus for at least 6 months * Age 18-90 years * A foot ulcer below the level of the malleoli. If more than one ulcer, the largest will be selected at screening as the index ulcer. * Wound area after sharp debridement of ≥ 5 mm2, but ≤ 3000 mm2. Exclusion Criteria: * Current use, or recent use (\<3 months), of GLP-1 agonists * Current use of DPP-IV inhibitors * Previous acute pancreatitis * Signs of infection of the index ulcer * Toe blood pressure \< 40 mmHg at the foot with the index ulcer * Current treatment with cytotoxic drugs or with systemically administered glucocorticoids * Hospitalisation for a major cardiovascular event or procedure or revascularization surgery on a leg in the last 3 months, or scheduled major cardiovascular intervention * Contraindication/intolerance to study medication * Pre-existing medical condition judged to preclude safe participation in the study * Abuse of alcohol or drugs, or presence of any condition that in the Investigators opinion may lead to poor adherence to study protocol * Recent use (\< 3 months) of an investigational drug or participation in interventional clinical foot ulcer-healing trial * Known pregnancy, breast feeding or planning pregnancy. * Women of childbearing potential (i.e. fertile, following menarche and until becoming post-menopausal unless permanently sterile (hysterectomy, bilateral salpingectomy and bilateral oophorectomy) without a confirmed menstrual period…