Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients

Inclusion Criteria: * Age 18 years or older * Admitted to the NSICU at UT Southwestern Medical Center * Informed consent obtained from subject or legally authorized representative (as defined under Texas Health and Safety Code Section 166.039), or consent process underway per institutional policy * At least one study monitoring modality feasible (SedLine qEEG and/or Brain4Care extensometry); NIRS data collected where already in standard clinical use Exclusion Criteria: * Age younger than 18 years * Prisoner status * Active declination of participation by subject or legally authorized representative * Absence of both subject and legally authorized representative consent when required * Clinical condition preventing safe placement of any study monitor (e.g., extensive facial or scalp injury, surgical dressings or hardware at all possible sensor sites, open wounds at sensor locations, severe uncontrolled agitation) * Anticipated clinical data capture insufficient for meaningful analysis * Urgent clinical priorities making research monitor placement inappropriate at time of approach * Inability to provide informed consent in English; study consent materials are available in English only