CLOT-LESS - CLOsure Tailored: LEss Antithrombotic Strategy After LAAC for Stroke Prevention

Inclusion Criteria: * Age ≥18 years; * Documented nonvalvular AF (≥30 seconds on ECG within previous 12 months); * CHA2DS2-VASc score ≥3 for women and ≥2 for men; * Signed informed consent to participate in the study; Exclusion Criteria: * Active indication for anticoagulation OTHER than atrial fibrillation at the time of enrollment and/or the predicted/unpredicted occurrence of such indications during the entire study period (e.g., mechanical valve, acute VTE, recent PE requiring \>3 months anticoagulation); * Inability to tolerate at least 3 months of apixaban therapy (for LAAC arm); * Indications for antiplatelet therapy or therapy with P2Y12 inhibitors at the time of inclusion and/or the predicted/unpredicted occurrence of such indications during the entire study period; * The presence of mechanical prosthetic heart valves, mitral stenosis of severe or moderate degree; * Active DVT requiring anticoagulation; * Congenital or acquired haemostasis disorders, rheumatic heart disease or recurrent deep vein thrombosis; * Left ventricular ejection fraction (LVEF) \< 30%; * Glomerular filtration rate (GFR) \< 30 ml/min (stage IV or V chronic kidney disease) or dialysis patient; * Severe liver failure, including cirrhosis and Child-Pugh Class C/D; * NYHA class IV congestive heart failure; * The patient had a myocardial infarction - MI with or without ST segment elevation (STEMI, NSTEMI) with or without intervention, within 30 days before LAAC; * The patient had a stroke (of any…