Lower Limb Strength and Power as Predictors of Brain Blood Flow During Exercise (NCT07575802) | Clinical Trial Compass
CompletedNot Applicable
Lower Limb Strength and Power as Predictors of Brain Blood Flow During Exercise
Russia256 participantsStarted 2025-03-01
Plain-language summary
This study aims to investigate the predictive value of lower limb muscle strength and explosive power on exercise-induced prefrontal hemodynamic responses. Using an interpretable machine learning framework (GCAT-Net), the research analyzes how various physical performance indicators-such as isokinetic muscle strength, 1RM leg press, and vertical jump metrics-can predict oxygenated hemoglobin (ΔHbO) changes in the bilateral dorsolateral prefrontal cortex (DLPFC) during moderate-intensity cycling.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Healthy adults aged between 18.00 and 60.00 years.
. Must be able to perform standardized lower-limb physical assessments, including isokinetic strength testing and explosive power tests (e.g., CMJ, SJ, and 30m sprints).
. Capability to complete a 6-minute aerobic cycling task at a moderate intensity (60% VO\_2max).
. Physically cleared for exercise as determined by a Physical Activity Readiness Questionnaire (PAR-Q).
. Willingness to undergo functional near-infrared spectroscopy (fNIRS) monitoring with a Scalp Coupling Index (SCI) ≥ 0.7.
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Area Under the Curve of Oxygenated Hemoglobin (Δ HbO AUC) during Aerobic Exercise
Timeframe: Measured during the 6-minute constant-load cycling task (60%VO_2max), which occurs approximately 120 minutes after the start of the experimental session.
. History of musculoskeletal injuries to the lower limbs within the past 6 months that would impede maximum voluntary contraction (MVC) or high-intensity efforts.
. Known cardiovascular, respiratory, or neurological conditions that contraindicate maximal exercise testing (VO\_2max ramp protocol).
. Body Mass Index (BMI) or health status that prevents the safe completion of high-impact explosive power tests like the 30cm drop jump (RSI assessment).
. Presence of excessive motion artifacts or poor fNIRS signal quality, specifically a Signal-to-Noise Ratio (SNR) \< 5 dB or motion artifact frame ratio ≥$ 10%.