CompletedNot Applicable

Lower Limb Strength and Power as Predictors of Brain Blood Flow During Exercise

Russia256 participantsStarted 2025-03-01

Plain-language summary

This study aims to investigate the predictive value of lower limb muscle strength and explosive power on exercise-induced prefrontal hemodynamic responses. Using an interpretable machine learning framework (GCAT-Net), the research analyzes how various physical performance indicators-such as isokinetic muscle strength, 1RM leg press, and vertical jump metrics-can predict oxygenated hemoglobin (ΔHbO) changes in the bilateral dorsolateral prefrontal cortex (DLPFC) during moderate-intensity cycling.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion criteria

✓. Healthy adults aged between 18.00 and 60.00 years.
✓. Must be able to perform standardized lower-limb physical assessments, including isokinetic strength testing and explosive power tests (e.g., CMJ, SJ, and 30m sprints).
✓. Capability to complete a 6-minute aerobic cycling task at a moderate intensity (60% VO\_2max).
✓. Physically cleared for exercise as determined by a Physical Activity Readiness Questionnaire (PAR-Q).
✓. Willingness to undergo functional near-infrared spectroscopy (fNIRS) monitoring with a Scalp Coupling Index (SCI) ≥ 0.7.

Exclusion criteria

✕. History of musculoskeletal injuries to the lower limbs within the past 6 months that would impede maximum voluntary contraction (MVC) or high-intensity efforts.
✕. Known cardiovascular, respiratory, or neurological conditions that contraindicate maximal exercise testing (VO\_2max ramp protocol).
✕. Body Mass Index (BMI) or health status that prevents the safe completion of high-impact explosive power tests like the 30cm drop jump (RSI assessment).
✕. Presence of excessive motion artifacts or poor fNIRS signal quality, specifically a Signal-to-Noise Ratio (SNR) \< 5 dB or motion artifact frame ratio ≥$ 10%.

What they're measuring

Area Under the Curve of Oxygenated Hemoglobin (Δ HbO AUC) during Aerobic Exercise

Timeframe: Measured during the 6-minute constant-load cycling task (60%VO_2max), which occurs approximately 120 minutes after the start of the experimental session.

Trial details

NCT IDNCT07575802

SponsorLincoln University College

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-15

View on ClinicalTrials.gov More Prefrontal Hemodynamics trials