The Effect of Lipedema on Knee Osteoarthritis (NCT07575555) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Effect of Lipedema on Knee Osteoarthritis
Turkey (Türkiye)76 participantsStarted 2026-07-15
Plain-language summary
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context. Although the relationship between obesity and osteoarthritis has been extensively studied in the literature, the effect of specific adipose tissue pathologies, such as lipedema, on osteoarthritis has not been sufficiently investigated. This study aims to demonstrate the independent effect of lipedema on osteoarthritis, evaluate clinical and ultrasonographic parameters together, and contribute to early diagnosis and targeted rehabilitation strategies.
Who can participate
Age range
30 Years – 65 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
All participants (Group 1 + Group 2)
* Women aged 30-65
* With a clinical and radiological diagnosis of knee osteoarthritis
* Who agreed to participate in the study
Group 1 (knee osteoarthritis with lipedema):
* Patients who meet the Wold criteria for a clinical diagnosis of lipedema
* An increase in subcutaneous fat thickness confirmed by ultrasound
Group 2 (knee osteoarthritis without lipedema):
* No diagnosis of lipedema
* Exclusion of lymphedema and venous diseases
Exclusion Criteria:
* Inflammatory arthritis
* History of knee surgery
* Intra-articular injection within the past 6 months
* Acute trauma
* Systemic connective tissue disease
* Severe venous insufficiency or lymphedema
* History of malignancy
* Use of gabapentinoids/SNRIs/SSRIs due to fibromyalgia or psychiatric illness
* Severe cognitive impairment or communication problems that would prevent participation in the study
* Pregnancy
* Participants who were informed about the study and refused to participate
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Ultrasonography-based measurements of femoral cartilage thickness