Effects of Multimodal Neuro Rehabilitation on Cortical Activity and Muscle Syenergy in Spastic Ce… (NCT07574996) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of Multimodal Neuro Rehabilitation on Cortical Activity and Muscle Syenergy in Spastic Cerebral Palsy
150 participantsStarted 2026-06-01
Plain-language summary
* To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy.
* To determine the retention effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy, one-month follow-up across the five groups.
Who can participate
Age range
6 Years – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Children aged 6-18 years.
* Neurologist-confirmed spastic cerebral palsy.
* GMFCS Levels I-III (mild to moderate motor impairment).
* Ability to understand and follow simple instructions.
* Medically stable (no planned major surgery; no recent adjustment of medications affecting cortical excitability).
* Parental/guardian written informed consent and child assent.
Exclusion Criteria:
* Active uncontrolled epilepsy or history of seizure in the last year.
* Metal implants in the head or implanted medical/electrical devices (e.g., cochlear implants, ventriculoperitoneal shunts, pacemakers).
* Significant visual or auditory impairments that would interfere with task performance.
* Severe behavioral or cognitive difficulties that would prevent safe application of tDCS or training tasks.
* Currently taking medications known to significantly alter cortical excitability (e.g., benzodiazepines, antiepileptics) if dosage is unstable.
* Participation in other experimental neurorehabilitation or brain stimulation interventions within the last 6 months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Cortical Activity
Timeframe: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
2
Change in Muscle Synergy Patterns
Timeframe: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
3
Measure Gross Motor Function children.
Timeframe: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
4
Measures balance in children.
Timeframe: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
5
Assesses walking speed in children
Timeframe: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up
6
Assesses mobility and balance in children
Timeframe: Baseline (pre-intervention), immediately post-intervention (6 weeks), and 1-month follow-up