A Phase II Study of Sintilimab, Pegaspargase and Selinexor Followed by Radiotherapy in Newly Diag… (NCT07574528) | Clinical Trial Compass
Not Yet RecruitingPhase 2
A Phase II Study of Sintilimab, Pegaspargase and Selinexor Followed by Radiotherapy in Newly Diagnosed Stage I/II Extranodal NK/T-Cell Lymphoma
China47 participantsStarted 2026-05-06
Plain-language summary
This is a single-arm, open-label, multicenter phase II study evaluating sintilimab, pegaspargase, and selinexor followed by radiotherapy as first-line treatment for patients with newly diagnosed stage I/II extranodal natural killer/T-cell lymphoma (ENKTL).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older.
* No prior systemic treatment for lymphoma, except short-term corticosteroids for symptom control.
* Life expectancy of more than 3 months.
* Eastern Cooperative Oncology Group performance status of 0 to 2.
* Histologically confirmed extranodal natural killer/T-cell lymphoma.
* Primary lesion located in the nasal cavity or upper aerodigestive tract.
* Stage I to II disease.
* At least one measurable or evaluable lesion according to Lugano 2014 criteria.
* Adequate organ and bone marrow function.
Exclusion Criteria:
* Aggressive NK-cell leukemia.
* Significant dysfunction of major organs.
* Known hypersensitivity to any study drug or its components, or contraindication to any study treatment.
* Pregnant or breastfeeding women, or participants of childbearing potential unwilling to use effective contraception.
* Known history of human immunodeficiency virus infection or acquired immunodeficiency syndrome.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.