Effects of Timed Restricted Eating on Body Composition, Metabolism, and Cardiovascular Health (NCT07574177) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of Timed Restricted Eating on Body Composition, Metabolism, and Cardiovascular Health
60 participantsStarted 2026-07
Plain-language summary
This study is looking at whether eating all meals within a 6-hour window each day (called Time-Restricted Eating, or TRE) can improve body composition, metabolism, heart health, and blood markers over 12 weeks. The study also wants to find out whether allowing participants to eat normally on weekends makes the diet easier to follow long-term.
Adults aged 18-65 with a BMI of 26 or higher who do not have heart disease or diabetes may be eligible. Participants will be randomly placed into one of two groups: (1) TRE every day for 12 weeks, or (2) TRE on weekdays with normal eating on weekends. All participants will visit the lab twice - once at the start and once at the end - for measurements of body fat, resting calorie burn, heart function, and blood tests. Between visits, participants will log their meals and steps at home and check in with the research team every two weeks.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Between 18 and 65 years of age
* Body mass index (BMI) of 26 kg/m² or higher (overweight or obese range)
* Physically inactive, defined as 150 minutes or less of moderate-intensity physical activity per week for the 3 months prior to enrollment
* No previous history of cardiovascular disease or Type 1 or Type 2 Diabetes Mellitus
* Not currently taking medications that may affect blood sugar, cholesterol, or body weight (e.g., glucose-lowering drugs, statins, or weight loss medications)
* Weight stable, defined as no more than 5 kg (about 11 lbs.) of body weight change in the 3 months prior to enrollment
* Willing and able to follow the study requirements, provide voluntary consent, and complete all study procedures
Exclusion Criteria:
* Younger than 18 or older than 65 years of age
* BMI below 26 kg/m²
* More than 150 minutes per week of moderate-intensity physical activity in the past 3 months
* History of cardiovascular disease or Type 1 or Type 2 Diabetes Mellitus
* Currently taking medications that may impact study outcomes
* Weight change of more than 5 kg in the past 3 months
* Pregnant, breastfeeding, or planning to become pregnant during the study
* History of an eating disorder
* Previous weight loss surgery (e.g., gastric bypass or sleeve gastrectomy)
* Unable to fast for approximately 18 hours at a time due to a medical condition
* Currently working night shifts
* Has a pacemaker or any implanted electronic device (due to bioimpedance spect…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.