Not Yet RecruitingPhase 3

Aspirin Versus Clopidogrel in Chronic Coronary Syndrome in Arabian Gulf Countries

6,740 participantsStarted 2027-04-01

Plain-language summary

Determine the long-term efficacy of clopidogrel compared with aspirin in reducing heart or brain attacks in patients with stable heart disease

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age ≥18 years.
✓. Significant coronary artery disease (coronary angiogram documentation of Left Main artery lesion ≥50% and/or lesion(s) ≥70% in other coronary arteries, and/or FFR\<0.8 or iFR\<0.9).
✓. Completed at least 6 months post ACS (regardless of the bleeding risk, anti-platelet strategy, revascularization strategy "PCI, CABG, or conservative medical management only", before randomization).
✓. Agreement to give written informed consent.

Exclusion criteria

✕. History of hypersensitivity to aspirin or clopidogrel.
✕. Presence of non-cardiac comorbidity with life expectancy ≤2 years from randomization.
✕. Plan for surgery or intervention which requires stopping antiplatelet agents ≥3 months.
✕. Females with childbearing potential or breast-feeding.
✕. Co-administration of contraindicated medications as follows: anticoagulants (warfarin, direct oral anticoagulants (DOACs), or chronic therapy of heparin); cytochrome P450 2C19 inhibitors (fluoxetine, moclobemid or voriconazole); probenecid; high dose of methotrexate (≥15 mg/week); lithium.
✕. Inability to have a complete follow-up for up to 5 years from randomization (e.g: high possibility of travelling outside the country).
✕. Inability to afford paying for Clopidogrel out-of-pocket up to 5 years from randomization (in case not being covered by the health care system).

What they're measuring

Four-point MACCE, defined as a composite of Cardiovascular Death, Non-fatal Myocardial Infarction, Non-fatal Ischemic Stroke, and Ischemia-driven Revascularization.

Timeframe: 3 years

Trial details

NCT IDNCT07572747

SponsorKhalid F Alhabib

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2032-04-01

Contact for this trial

Khalid Alhabib

+966505403354 khalidalhabib13@hotmail.com

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