Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults (NCT07572266) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults
United States226 participantsStarted 2026-05
Plain-language summary
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments to compromise intrinsic capacity and healthspan. Exercise is the only multipotent treatment with promise to mitigate many of the aging hallmarks, but there is substantial variability in individual exercise responsiveness. Thus, the investigators approach to boosting exercise responsiveness in aging is to combine an exercise training prescription containing both endurance and resistance training (in alignment with DHHS guidelines) with a nitrate-enriched dietary supplement to augment the cellular, tissue, and systemic adaptations that induce myriad health benefits of exercise in older adults.
Who can participate
Age range60 Years
SexALL
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Inclusion criteria
✓. Male or female aged 60 years or older
✓. Free of chronic disease or disorder that would preclude full participation or have the potential to confound results
✓. No structured exercise program (2 or more bouts/wk) within previous 12 months
✓. Cognitively capable of providing informed consent
Exclusion criteria
✕. BMI ≥ 30.0 kg/m2
✕. Neurodegenerative disease
✕. Neuromuscular, musculoskeletal or orthopedic disorder or condition that would limit ability to perform the exercise prescription and/or physical performance testing
✕. Diagnosed orthostatic hypotension, i.e., a drop in systolic blood pressure of at least 20 mmHg or a drop in diastolic blood pressure of at least 10 mmHg within three minutes of standing up from a sitting or lying position.
✕. Resting blood pressure \<90/60 mmHg or \>160/95 mmHg
What they're measuring
1
Assess the clinical impact of nitrate supplementation on a proportion of older adults attaining exercise-induced health benefits.
Timeframe: 12 weeks
Trial details
NCT IDNCT07572266
SponsorFlorida Institute for Human and Machine Cognition