CompletedNot Applicable

Gingival Crevicular Fluid Levels of Prolactin Hormone in Obese Patients With Stage ii and Iii Periodontitis Before and After Non-surgical Periodontal Therapy

Egypt26 participantsStarted 2024-10-01

Plain-language summary

Obesity and periodontitis are among the most common chronic disorders affecting the world population, while Prolactin (PRL) is a neuroendocrine hormone that within the physiological range stimulates bone formation while mild to marked increase in its level induces bone resorption and inhibits bone formation. Aim of the study: study aims to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF) in obese (O) patients with and without stage II and III periodontitis (P). Further, to evaluate the effect of non-surgical periodontal therapy on these levels compared to controls.

Who can participate

Age range25 Years – 55 Years

SexFEMALE

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Inclusion Criteria: * Body mass index (more than 29.9 kg/m2). * stage II and III periodontitis Exclusion Criteria: * Pregnancy or lactation. * Any known systemic disease other than obesity * Previous periodontal treatment (surgical or non-surgical) in last 6 months; * Antibiotics in the past 3 months. * Smoking

What they're measuring

change in clinical attachment level

Timeframe: Baseline and 3 months

change in GCF levels of prolactin hormone

Timeframe: Baseline and 3 months

Trial details

NCT IDNCT07571850

SponsorAlexandria University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-30

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