Colchicine for Autoimmune and Subacute Thyroiditis (NCT07571681) | Clinical Trial Compass
Not Yet RecruitingPhase 2/3
Colchicine for Autoimmune and Subacute Thyroiditis
300 participantsStarted 2026-07
Plain-language summary
Thyroiditis includes inflammatory thyroid disorders such as Hashimoto's thyroiditis and subacute thyroiditis. These conditions may cause thyroid pain, neck tenderness, elevated inflammatory markers, thyroid dysfunction, fatigue, and recurrence. Current management includes observation, symptomatic treatment, nonsteroidal anti-inflammatory drugs, and corticosteroids. Although corticosteroids may be effective, relapse after tapering and treatment-related adverse effects remain limitations. Colchicine is hypothesized to reduce inflammatory activity and may improve biochemical and clinical recovery. This study will evaluate the efficacy and safety of low-dose colchicine compared with corticosteroid therapy and supportive care in adults with autoimmune or subacute thyroiditis.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 to 70 years
* Newly diagnosed Hashimoto's thyroiditis or Subacute thyroiditis
* Diagnosis confirmed clinically, biochemically, and ultrasonographically
* Ability to provide written informed consent
Exclusion Criteria:
* Pregnancy or breastfeeding
* Severe renal impairment
* Severe hepatic disease
* Cytopenia
* Active serious infection
* Known hypersensitivity to colchicine
* Chronic corticosteroid use within previous 30 days
* Participation in another interventional trial
* Any condition affecting safety or protocol adherence
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean Change in C-Reactive Protein (CRP)
Timeframe: Baseline, Month 3, Month 6
2
Mean Change in Erythrocyte Sedimentation Rate (ESR)
Timeframe: Baseline, Month 3, Month 6
3
Mean Change in Thyroid Pain and Inflammatory Symptom from Baseline