A Study Of Synthetic THC And Sleep (NCT07570953) | Clinical Trial Compass
Not Yet RecruitingPhase 2/3
A Study Of Synthetic THC And Sleep
United States72 participantsStarted 2026-04
Plain-language summary
The purpose of this study is to determine if oral dronabinol prior to sleep can improve CPAP adherence and sleep quality in humans. We also seek to determine if combination therapy of CPAP and pre-sleep dronabinol is associated with improved BP regulation. We will also explore BP regulatory mechanisms and whether these are impacted differently between traditional CPAP therapy and combination CPAP/dronabinol.
Who can participate
Age range
21 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* 21 - 70 years of age
* Biological male or female
* AHI between 15 - 50 events/hour
Exclusion Criteria
* BMI \> 35 kg/m2
* Diagnosed psychiatric disorders
* Hypotension
* History of seizures
* History of substance abuse or recreational drug use or positive urine drug screen
* History of uncontrolled disease including:
* Cardiovascular
* Pulmonary
* Gastrointestinal
* Pancreatic
* Hepatic
* Renal
* Hematological
* Endocrine (including Type I Diabetes)
* Neurological
* Urological
* Pregnant or breastfeeding
* Use of certain antimicrobial, chemotherapeutic, anticoagulant, hypoglycemic, anti-inflammatory, psychotropic, and antihistamine drugs
* Prescribed CYP2C9 and/or CYP3A4 inhibitors
* Severe OSA that in the investigator's judgment should only begin CPAP treatment
* Prior upper airway surgery for snoring or OSA as an adult
* Significant defect in nasal patency due to anatomical abnormality or uncontrolled rhinitis
* Bariatric surgery within 2 years
* Medically managed weight-loss program within 6 months
* Noninvasive treatment for OSA within 1 month (self-report)
* History of shift work or rotating shifts within 1 month
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.