The purpose of this study is to determine if oral dronabinol prior to sleep can improve CPAP adherence and sleep quality in humans. We also seek to determine if combination therapy of CPAP and pre-sleep dronabinol is associated with improved BP regulation. We will also explore BP regulatory mechanisms and whether these are impacted differently between traditional CPAP therapy and combination CPAP/dronabinol.
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Number of times subjects complete CPAP therapy
Timeframe: Baseline
Apnea-hypopnea index (AHI)
Timeframe: Day 15, Day 29, and Day 42
International Physical Activity Questionnaire
Timeframe: Baseline and Day 42