Resveratrol for Endothelial Dysfunction and Metabolic Control in Type 2 Diabetes (NCT07569744) | Clinical Trial Compass
CompletedNot Applicable
Resveratrol for Endothelial Dysfunction and Metabolic Control in Type 2 Diabetes
Indonesia48 participantsStarted 2026-05-01
Plain-language summary
Type 2 diabetes mellitus is associated with endothelial dysfunction, which contributes to increased cardiovascular risk. Chronic hyperglycemia induces oxidative stress and reduces nitric oxide bioavailability, leading to impaired endothelial function. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, has been shown to improve endothelial function in experimental studies.
This randomized controlled trial aims to evaluate the effectiveness of resveratrol supplementation in improving endothelial dysfunction and metabolic control in patients with type 2 diabetes mellitus. Endothelial function will be assessed using flow-mediated dilatation (FMD) of the brachial artery and serum endothelial nitric oxide synthase (eNOS) levels. Metabolic parameters including fasting blood glucose, postprandial glucose, HbA1c, and lipid profile will also be evaluated.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18-65 years
* Diagnosed with type 2 diabetes mellitus
* Evidence of endothelial dysfunction
* Stable antidiabetic therapy for at least 3 months prior to enrollment
* Willing to participate and provide informed consent
Exclusion Criteria:
* Type 1 diabetes mellitus
* Acute or chronic infection
* History of cardiovascular events (e.g., myocardial infarction, stroke)
* Severe renal impairment or hepatic dysfunction
* Pregnancy or breastfeeding
* Use of antioxidant supplements or investigational drugs within the last 3 months
* Known allergy or contraindication to resveratrol
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial tested resveratrol specifically for endothelial dysfunction in type 2 diabetes — given that the study is now completed, has any data been published yet, and if so, did the results show any meaningful changes in blood vessel function as measured by that brachial artery flow test?
2The trial measured something called Flow-Mediated Dilatation and a marker called eNOS — can you explain what those actually tell us about blood vessel health in diabetes, and whether improving those numbers would translate to real benefits for me?
3Since this trial has no assigned phase, which usually means it's more of an early or exploratory study, how much weight should I give its findings when deciding whether resveratrol is worth considering alongside my current diabetes management?
4Resveratrol is a supplement that's already widely available over the counter — does the fact that this trial has completed change your thinking about whether I should discuss trying it, or is it too early to draw conclusions without seeing the full results?
5Are there standard treatments for endothelial dysfunction in type 2 diabetes that already have stronger evidence behind them, and would it make more sense to optimize those first before considering anything based on this trial's findings?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Flow-Mediated Dilatation (FMD) of the Brachial Artery
Timeframe: Baseline and 12 weeks
2
Change in Serum Endothelial Nitric Oxide Synthase (eNOS) Levels