By InvitationNot Applicable

The Effect of Remifentanil on the Objectively Measured Pressure Pain Threshold

Belgium40 participantsStarted 2026-01-26

Plain-language summary

It is a clinical study investigating the relationship between objectively measured pain threshold and the need for escalating doses of remifentanyl opioids. This study is expected to include approximately 40 participants. The aim of the study is to objectively measure the analgesic effect of an increasing dose of opioids just before anesthesia.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients who are able to volunteer * ASA 1, 2and 3 Exclusion Criteria: * Refusal to participate; * Body mass index (BMI) \> 30 kg/m²; * Allergy to any medication used for anesthesia; * Chronic pain or regular use of analgesics; * Severe ventricular dysfunction, pulmonary hypertension, or uncontrolled arrhythmia; * Non-elective surgery; * Participation in another study within the last 3 months; * Pregnancy or breastfeeding; * Severe renal or hepatic impairment

What they're measuring

Measurement of the variation in the pressure pain threshold

Timeframe: Measurement of the mechanical pressure pain threshold will be initiated upon the participant's arrival in the operating room. The procedure is expected to last approximately 10-15 minutes and will be followed by induction of anesthesia.

Trial details

NCT IDNCT07568405

SponsorUniversité Libre de Bruxelles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-15

View on ClinicalTrials.gov More Pain Threshold trials