The Effect of Remifentanil on the Objectively Measured Pressure Pain Threshold (NCT07568405) | Clinical Trial Compass
By InvitationNot Applicable
The Effect of Remifentanil on the Objectively Measured Pressure Pain Threshold
Belgium40 participantsStarted 2026-01-26
Plain-language summary
It is a clinical study investigating the relationship between objectively measured pain threshold and the need for escalating doses of remifentanyl opioids. This study is expected to include approximately 40 participants.
The aim of the study is to objectively measure the analgesic effect of an increasing dose of opioids just before anesthesia.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients who are able to volunteer
* ASA 1, 2and 3
Exclusion Criteria:
* Refusal to participate;
* Body mass index (BMI) \> 30 kg/m²;
* Allergy to any medication used for anesthesia;
* Chronic pain or regular use of analgesics;
* Severe ventricular dysfunction, pulmonary hypertension, or uncontrolled arrhythmia;
* Non-elective surgery;
* Participation in another study within the last 3 months;
* Pregnancy or breastfeeding;
* Severe renal or hepatic impairment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Measurement of the variation in the pressure pain threshold
Timeframe: Measurement of the mechanical pressure pain threshold will be initiated upon the participant's arrival in the operating room. The procedure is expected to last approximately 10-15 minutes and will be followed by induction of anesthesia.