RecruitingNot Applicable

Evaluation of the Clinical Efficacy and Mechanisms of Cord Plasma Eye Drops in the Treatment of Neuropathic Corneal Pain

Singapore20 participantsStarted 2023-09-16

Plain-language summary

The goal of this clinical trial is to investigate the efficacy and work of action of cord plasma eye drops in the treatment of neuropathic corneal pain (NCP). The main question it aims to answer if the cord plasma eye drops are effective for the treatment of NCP through its neurotrophic and anti-neuroinflammatory effects.

Who can participate

Age range21 Years

SexALL

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Inclusion criteria

✓. Persistent ocular pain or pain-like symptoms, including burning sensation, allodynia, photoallodynia, stinging, hyperalgesia, throbbing, shooting, sharp, cramping, gnawing, or a feeling of electric shock, with a minimum score of 30% for more than 3 questions in the OPAS questionnaire (see below section for OPAS questionnaire), for at least 3 months;
✓. Presence of corneal nerve abnormalities, including microneuromas, beading, nerve tortuosity, decreased in corneal nerve fiber density (CNFD) or corneal nerve fiber length (CNFL), on IVCM images;
✓. Minimal or no ocular surface fluorescein staining, with the National Eye Institute (NEI) and ocular surface Oxford score \<2;
✓. Patients who will receive cord plasma eye drops treatment

Exclusion criteria

✕. Presence of active ocular surface diseases, such as active infective keratitis, the presence of epithelial defect or any other conditions that may cause nociceptive pain
✕. Active anterior or posterior blepharitis;
✕. Presence of concomitant ocular diseases that may cause ocular pain, such as uveitis or other ocular inflammatory diseases;
✕. Concurrent treatment with immunosuppressants, such as topical cyclosporin or steroid eye drops
✕. Concurrent use of oral Nonsteroidal anti-inflammatory drugs (NSAID) or other medications that may affect the pain scores

What they're measuring

Pain symptoms evaluated by Ocular Pain Assessment Survey (OPAS) questionnaire

Timeframe: 3 months

Corneal nerve morphology assessment by in vivo confocal microscopy (IVCM)

Timeframe: 3 months

Trial details

NCT IDNCT07566806

SponsorSingapore Eye Research Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-15

Contact for this trial

Yu-Chi Liu, PhD

65 65767493 liu.yu.chi@snec.com.sg

View on ClinicalTrials.gov More Neuropathic Pain trials