Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence (NCT07565714) | Clinical Trial Compass
RecruitingNot Applicable
Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence
Poland40 participantsStarted 2026-04
Plain-language summary
The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs). Intervention will involve the prior presentation of the most aversive fragment of the memory, the so-called 'hotspot.' This intervention will allow for the replication of the effect described by Dibbets and Arntz (2016), according to which the prior activation of the most emotional element of a memory enhances the effectiveness of ImRs.
The study is also significant due to another ongoing study in which a substantial number of participants have already been examined; however, due to the exhaustion of funds, it was not possible to utilize the remainder of the recruited sample. Investigating an additional condition will allow for a more complete utilization of the available participant pool and significantly increase the project's scientific value by comparing the traditional ImRs mechanism with its AI-generated version.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-35
* Score ≥ 8 on GAD-7 (Plummer et al., 2016)
* Ability to recall at least two childhood memories involving parental criticism
Exclusion Criteria:
* History of prolonged physical or sexual abuse
* Current psychotherapy or psychopharmacology
* PTSD diagnosis (DSM-5 screening)
* Substance abuse (TAPS tool)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses generative AI to assist with a therapy technique called imagery rescripting — can you explain what that process actually involves day-to-day, and whether it sounds appropriate for where I am right now with my anxiety or fear of failure?
2Since this trial is listed as 'Phase NA,' it seems to be a psychological research study rather than a drug trial — what does that mean for what's already known about the safety and effectiveness of AI-assisted imagery rescripting compared to more established therapies for generalized anxiety?
3The study is measuring things like skin conductance and intrusive thought frequency, which suggests it involves monitoring my physiological and emotional responses — how time-intensive or emotionally demanding might that be, and is that realistic given my current situation?
4Given that this study targets generalized anxiety, fear of failure, and rumination specifically, do you think my particular symptoms match closely enough that this could be a good fit, or would a more standard treatment path make more sense to try first?
5If I were to discuss this trial with a researcher or coordinator, what questions should I be asking them about how the AI component works and what safeguards are in place to make sure it's being used responsibly in a mental health context?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Generalized Anxiety Disorder DSM Scale (GAD)
Timeframe: Screening, Pre-intervention (Day 1) and 1-week follow-up
2
The Performance Failure Appraisal Inventory
Timeframe: Pre-intervention (Day 1)
3
Intrusive Thought Frequency (Rumination Inventory - adapted)
Timeframe: Pre-intervention (Day 1) and 1-week follow-up
4
Skin Conductance Level (SCL)
Timeframe: During experiment/intervention (Day 1)
5
Emotional Response Ratings (Subjective)
Timeframe: During experiment/intervention (Day 1)
Trial details
NCT IDNCT07565714
SponsorUniversity of Social Sciences and Humanities, Warsaw