Not Yet RecruitingNot Applicable

Effect of aiTBS on Intrinsic Spectral Dynamics and Task Performance

80 participantsStarted 2026-06-01

Plain-language summary

Aim 1: Measure local shifts in cortical spectral dynamics following aiTBS. Aim 2: Measure network-specific shifts in task performance following aiTBS. Exploratory aim: Evaluate changes to resting state spectral dynamics in absence of stimulation after aiTBS.

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Able to give their consent * Right-handed or ambidextrous Exclusion Criteria: * Non-english speaking * Current or past non-anxiety-related psychiatric comorbidity. * Active or history of active suicidal ideation * Alcohol/drug problems in the past year or lifetime alcohol or drug dependence * Medications that act on the central nervous system * History of seizure * History of epilepsy * Increased risk of seizure for any reason * Pregnancy, or positive pregnancy test * Any medical (e.g., stroke, breathing problems, motion disorders) or neurological (e.g., a significant brain injury or brain infection history that increases seizure risk) condition that increases risk for fMRI or TMS (Protocol will follow recommendations from Rossi et al. 2021 doi:10.1016/j.clinph.2020.10.003) * Any metal in their body which would make having an MRI scan unsafe * Any sort of medical implants * Hearing loss * Claustrophobia * orthostatic hypotension

What they're measuring

Spectral Dynamics

Timeframe: Participants will undergo six study visits spaced over a 2-week period. Outcome measures will be collected during study visits 2-6 during week 2.

Task Performance

Timeframe: Participants will undergo six study visits spaced over a 2-week period. Outcome measures will be collected during study visits 2-6 during week 2.

Trial details

NCT IDNCT07565207

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-05-30

Contact for this trial

Nicholas Balderston

12157463058 nicholas.balderston@pennmedicine.upenn.edu

View on ClinicalTrials.gov More Brain Plasticity trials

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Spectral Dynamics

Timeframe: Participants will undergo six study visits spaced over a 2-week period. Outcome measures will be collected during study visits 2-6 during week 2.

Task Performance

Timeframe: Participants will undergo six study visits spaced over a 2-week period. Outcome measures will be collected during study visits 2-6 during week 2.