CompletedPhase 4

Effect of Zinc Oxide Ointment on Recurrent Aphthous Stomatitis

Egypt100 participantsStarted 2025-06-30

Plain-language summary

This randomized placebo-controlled trial evaluated the effectiveness of zinc oxide ointment in the treatment of recurrent aphthous stomatitis (RAS). The study included 100 patients randomly assigned to receive either zinc oxide ointment or a placebo, applied three times daily for six days. Pain intensity was measured using a visual analogue scale (VAS), and oral health-related quality of life was assessed using OHIP-14 at baseline and on days 1, 3, and 6.

Who can participate

Age range16 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * -Systemically healthy subjects suffering from minor oral RAS. * Patients of both sexes, aged 16-45 years (to avoid the potential effects of age on healing). * Participants had not received any treatment for the ulcers before being included in the study and had no active periodontitis. * Ulcers are of a duration of less than 48 hours. Exclusion Criteria: * -Participants with removable prosthetic or orthodontic appliances (to avoid potential effects on healing). * Tobacco chewers, smokers or alcoholics. * Pregnant or lactating females. * Patients who had previously or are presently taking medications that could affect events associated with the healing process (erg, corticosteroids, oral antidiabetics, non-steroidal anti-inflammatory drugs, immune-modulating agents).

What they're measuring

Visual analog scale

Timeframe: Before treatment ,Day 1,Day 3 and Day 6

Trial details

NCT IDNCT07565181

SponsorFaculty of Dental Medicine for Girls

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2026-01-30

View on ClinicalTrials.gov More Recurrent Aphthous Stomatitis trials