Active — Not RecruitingNot Applicable

Correlation and Heterogeneity of the Immune Microenvironment and Histopathological Growth Patterns in Resectable Colorectal Cancer Liver Metastases

China64 participantsStarted 2018-01-01

Plain-language summary

Who can participate

Sex

ALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with CRLM who underwent R0 resection * Histologically or cytologically confirmed CRLM * Have sufficient liver metastasis tissue specimens available for analysis * Complete treatment and follow-up records Exclusion Criteria: * Patients did not undergo R0 resection * Postoperative specimens were unavailable * Clinical data were incomplete.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

OS(Overall survival)

Timeframe: OS is defined as the time from the date of the first liver metastasis resection to death due to any cause or loss to follow-up, assessed up to 100 months.

RFS (Recurrence-free Survival)

Timeframe: From the date of liver resection until the first occurrence of a measurable recurrence of the disease, or until death due to any cause (whichever occurs first), the assessment period can be up to 100 months.

HGPs (Histopathological Growth Patterns)

Timeframe: From the completion of HE staining to the failure of staining or the damage and loss of the slides, the assessment period can be up to 100 months.

TME (Tumor Microenvironment)

Timeframe: From the completion of mIHC staining to the failure of staining or the damage and loss of the slides, the assessment period can be up to 100 months.

Trial details

NCT IDNCT07564908

SponsorMeng Qiu

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2030-12-30

View on ClinicalTrials.gov More Colorectal Neoplasms trials