This randomized, double-blind, crossover human laboratory study compares the abuse liability of cigarettes containing menthol and non-menthol cigarette variants, using the participant's usual brand menthol cigarette as a within-subject reference. Participants complete standardized laboratory smoking sessions, behavioral economic tasks, and a naturalistic observational period. The study examines differences in nicotine delivery, smoking behavior, and subjective effects across cigarette types in laboratory and real-world contexts.
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Plasma nicotine (Cmax)
Timeframe: During Phase 1 and 2 smoking sessions, assessed up to 3 weeks
The Ohio State University Comprehensive Cancer Center