Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)

Inclusion Criteria: * Absence of symptoms and history of cardiovascular and cerebrovascular diseases. * Baseline blood pressure levels within the normal range (\< 140/90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications. Exclusion Criteria: * Diabetes Mellitus: Fasting blood glucose ≥ 126 mg/dL or use of hypoglycemic agents. * Smoking: Active or quit less than 5 years ago. * Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes. * Surgery or trauma in the last 60 days. * Renal Dysfunction: Chronic renal failure (estimated by eGFR \< 60 mL/min/1.73m²). * Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).