Active — Not RecruitingPhase 4

Possible Augmentation Of NB-UVB Induced Pigmentation In NSV By Carboxy.

Egypt59 participantsStarted 2024-09-15

Plain-language summary

Patients with stable vitiligo with 2 or more symmetric patches, 2 on acral sites and/or 2 on non acral sites will be recruited and assessed for eligibility for inclusion to receive NB-UVB on the whole body, and carboxytherapy on one randomized side.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Subjects with stable non-segmental vitiligo (≥2 symmetrical patches of diameter less than 2 cm on acral or ≥ 2 symmetrical patches on non-acral sites). Subjects were stable for twelve or more months. Exclusion Criteria: * Subjects with unstable vitiligo. * Subjects with segmental vitiligo. * Pregnant females. * Severe anemia (Hb \<7 gm/dl). * Cardiac/hepatic/renal/respiratory failure. * Superficial thrombophlebitis. * Subjects with history of skin malignancy or precancerous conditions like Xeroderma pigmentosum. * Subjects with other autoimmune disorders. * Systemic drugs for vitiligo in the last 3 months.

What they're measuring

Vitiligo Extent Score for a Target Area (VESTA)

Timeframe: 6 months- 1 year

Estimation of human E-Cadherin using ELISA

Timeframe: 6 months -1 year

Estimation of malondialdehyde by spectrophotometer

Timeframe: 6 months-1 year

Trial details

NCT IDNCT07563049

SponsorKasr El Aini Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-22

View on ClinicalTrials.gov More Vitiligo Vulgaris trials