By InvitationNot Applicable

Whole Genome-Based Surveillance of Nasopharyngeal Pneumococcal Carriage in Vietnamese Children

Vietnam530 participantsStarted 2026-04-01

Plain-language summary

This hospital-based cross-sectional study aims to determine the prevalence and serotype distribution of nasopharyngeal Streptococcus pneumoniae carriage among children aged 2-59 months hospitalized with acute respiratory symptoms at Vietnam National Children's Hospital (VNCH). Whole genome sequencing (WGS) will be used for serotype identification, antimicrobial resistance gene detection, and characterization of co-colonization patterns. The study will compare carriage prevalence and serotype distribution between previously healthy children and children with underlying comorbidities. Findings will inform pneumococcal vaccine policy and antimicrobial resistance surveillance in Vietnam.

Who can participate

Age range2 Months – 5 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 2 months to 59 months * Hospitalized with acute respiratory symptoms (≤14 days duration) * Parent or legal guardian provides written informed consent Acute respiratory symptoms defined as one or more of: * Cough * Rhinorrhea * Nasal obstruction * Sore throat * Tachypnea * Wheeze * Retraction Exclusion Criteria: * Confirmed pneumococcal infection within the past 30 days

What they're measuring

Prevalence of Pneumococcal Carriage

Timeframe: At enrollment

Pneumococcal Serotype Distribution

Timeframe: At enrollment

Trial details

NCT IDNCT07562529

SponsorPhuc Huu Phan

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-06-30

View on ClinicalTrials.gov More Streptococcus Pneumoniae Carriage trials