Load Incorporating Cardiac Assessment by Echocardiography In Patients With SEpsis (LIAISE Study) (NCT07562217) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Load Incorporating Cardiac Assessment by Echocardiography In Patients With SEpsis (LIAISE Study)
Australia200 participantsStarted 2026-05-01
Plain-language summary
The LIAISE study is a prospective observational study comparing the performance of load-incorporating echocardiographic parameters and conventional parameters in predicting adverse events among adult patients presenting to the ICU with sepsis. It will be conducted in hospitals in Australia, Hong Kong, South Africa, and Canada, with 199 patients recruited over 2 years. All included patients will receive an regular echocardiographic assessment and their haemodynamic parameters will be simultaneously recorded. Participants will be followed for up to 1 year after enrolment. Load incorporating parameters will be derived from regularly obtained echocardiography and haemodynamic data during offline analysis. The predictive value of cardiac parameters will be evaluated based on their statistical association with clinical outcomes.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Adults ≥ 18 years old.
. Clinically suspected of defined sepsis
. Sepsis-induced hypotension or hypoperfusion (arterial or venous blood lactate ≥2.0 mmol/L OR mean artery pressure ≤65 mmHg over 30 mins OR at least one vasoactive or inotropic agent administered).
. At least one dose of an IV antimicrobial has been commenced.
Exclusion criteria
. Suspected or confirmed pregnancy.
. Any severe concomitant diseases with limited life expectancy \<30 days.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is called LIAISE and seems to use echocardiography — which is a heart ultrasound — to guide fluid management in sepsis; can you explain how that approach differs from how my fluid treatment would normally be decided, and whether that difference matters for my specific situation?
2Since this study is measuring 'all cause death' as its primary outcome, it sounds like it's trying to find out whether this approach actually saves lives — what does that tell us about how much is already known about whether echocardiography-guided fluid loading is better than standard care?
3The trial isn't recruiting yet, so there's no guarantee of when or whether it will open — given that sepsis needs to be treated urgently, what are my realistic options for getting involved, and would waiting for this trial ever make sense?
4If I were enrolled, would I potentially receive a different fluid management strategy than what you'd normally recommend, and is there any risk that the echocardiography-guided approach could lead to me receiving too much or too little fluid?
5Given that this is a study still in the planning stage with no assigned phase, would you recommend I focus on proven standard treatments for my sepsis first, or is there a realistic path where discussing this trial is worth our time right now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.