By InvitationNot Applicable

SER-ABS-AUD: Bio-Psycho-Socio-Spiritual Predictors of AUD Recovery

Romania70 participantsStarted 2026-04-20

Plain-language summary

Alcohol use disorder (AUD) remains a major public health burden in Romania, with very high alcohol-attributable mortality and years of life lost. Conventional treatment focuses on achieving abstinence, but the distinction between "struggle abstinence" (persistent cravings, anhedonia, white-knuckle willpower) and "serene abstinence" (anhedonia resolution, restored reward, meaning and quality of life) is poorly characterized in the Romanian context. This longitudinal observational study uses the Millon Clinical Multiaxial Inventory-IV (MCMI-IV) together with a brief neuropsychosocial-spiritual battery to identify which personality patterns and clinical syndromes predict serene versus struggle abstinence in adults with DSM-5 alcohol use disorder who maintain at least 12 months of sobriety in Romanian community recovery settings.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion Criteria: * Diagnosis of Alcohol Use Disorder according to DSM-5 or ICD-10 criteria documented in clinical records. * Minimum 12 consecutive months of alcohol abstinence prior to baseline assessment (self-report corroborated by group leaders/clinical notes where available). * Current or recent participation (last 12 months) in at least one recovery support program (ACAR support groups and/or Don Orione recovery services). * Ability to understand study procedures and provide written informed consent in Romanian. Exclusion Criteria: * Acute psychiatric conditions requiring emergency intervention (e.g. psychotic episode, severe mania) at screening. * Active suicidal risk (positive PHQ-9 item on suicidal ideation with associated clinical concern) requiring urgent care. * Uncontrolled comorbid substance use disorder (e.g. ongoing illicit drug dependence) that would confound assessment of alcohol-related recovery. * Legal incapacity or inability to provide informed consent. * Severe cognitive impairment (e.g. MMSE below functional threshold) precluding valid questionnaire completion (to be screened where indicated).

What they're measuring

Serene Abstinence Index at 12 Months (Binary: Serene vs Struggle Abstinence)

Timeframe: 1 year

Trial details

NCT IDNCT07561749

SponsorGrigore T. Popa University of Medicine and Pharmacy

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-09-01