CompletedNot Applicable

Ablation With Systemic Therapy vs Liver Resection With Systemic Therapy for Colorectal Liver Metastasis

China151 participantsStarted 2018-01-01

Plain-language summary

For patients with colorectal liver metastases (CRLM) ≤5 cm, Clinical guidelines recommend surgery, but a growing number of studies have shown that thermal ablation is as effective as surgery. However, the optimal treatment strategy remains unclear.This study aimed to compare outcomes between patients who underwent ablation with systemic therapy or liver resection with systemic therapy for CRLM less than 5 cm in diameter.

Who can participate

Age range18 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 18 and 85 years. * Primary tumor resected with R0 resection and pathological confirmation of colorectal adenocarcinoma. * Liver metastasis confirmed by any two of the following examinations: contrast-enhanced CT, enhanced MRI, CEUS, PET-CT, or pathology. * Liver metastases with maximum diameter ≤ 5 cm and ≤ 5 lesions. Exclusion Criteria: * History of other local treatments for liver metastasis prior to ultrasound-guided microwave ablation/liver resection. * With concurrent extrahepatic metastases. * With concurrent other malignancies. * With incomplete clinical data.

What they're measuring

Progression-Free Survival (PFS)

Timeframe: 1year

Trial details

NCT IDNCT07559851

SponsorThe First Hospital of Jilin University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-03-01

View on ClinicalTrials.gov More Colorectal Liver Metastasis (CRLM) trials