Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression (NCT07559344) | Clinical Trial Compass
RecruitingNot Applicable
Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression
France96 participantsStarted 2026-02-16
Plain-language summary
Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts.
This study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.
Who can participate
Age range
19 Years – 25 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Sex: Healthy, athletic men practicing track and field (10 to 12 hours/week)
* Age: 19 to 25 years old
* Social security coverage
* Signed informed consent
Exclusion Criteria:
* Age over 26 years
* Low level of physical activity (less than 8 hours per week)
* Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb (within the last 8 months)
* Exposure to an altitude of 2500m within 15 days prior to the protocol
* Presence of arterial hypotension:
* Systolic blood pressure below 90 mmHg
* Diastolic blood pressure below 60 mmHg
* A drop in systolic blood pressure greater than 20 mmHg upon moving from a lying to a standing position.
* A drop in diastolic blood pressure greater than 10 mmHg upon moving from a lying to a standing position.
* Presence of dizziness, lightheadedness, or blurred vision upon moving from a lying to a standing position.
* Participant under guardianship/conservatorship or deprived of liberty.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.