Dexmedetomidine in Attenuation of Haemodynamic Response to Laryngoscopy in Controlled Hypertensiv… (NCT07557680) | Clinical Trial Compass
CompletedPhase 3
Dexmedetomidine in Attenuation of Haemodynamic Response to Laryngoscopy in Controlled Hypertensive Patients
Pakistan70 participantsStarted 2025-01-01
Plain-language summary
This randomized control trial, which was carried out at Sindh Institute of Urology and Transplantation (SIUT), used a non-probability consecutive sampling technique for six months from January 1, 2025, to June 30, 2025.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Ages from 18 to 65 years.
* Patients with a known case of controlled hypertension.
* ASA II
* Elective surgical procedure under general anaesthesia.
* Mallampati grades 1 and 2.
* Patients consenting to participate in this study
Exclusion Criteria:
* Patients with an anticipated difficult intubation.
* Those requiring more than 15 seconds or more than one attempt or use of a bougie during laryngoscopy.
* A patient who has not taken an antihypertensive drug early morning on the day of surgery.
* Patients with a history of allergy to drugs being used.
* Patients with uncontrolled hypertension (BP \> 140/90 mmHg).
* History of bradycardia (resting heart rate \< 60 bpm).
* Patients on beta blockers if resting heart rate \< 60 bpm.
* History of valvular heart disease, uncontrolled diabetes, liver, or kidney disease.
* Pregnancy.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Heart Rate via 3 lead ECG monitor
Timeframe: Perioperative
2
Systolic Blood Pressure measured via a non invasive blood pressure device
Timeframe: Perioperative
3
Diastolic Blood Pressure measured via a non invasive blood pressure device
Timeframe: Perioperative
4
Mean Blood Pressure measured via a non-invasive blood pressure device
Timeframe: Perioperative
Trial details
NCT IDNCT07557680
SponsorSindh Institute of Urology and Transplantation