Not Yet RecruitingNot Applicable

Opportunistic Breast Cancer Screening Using Non-Contrast Chest CT

China5,000 participantsStarted 2026-05-01

Plain-language summary

The goal of this observational study is to evaluate the feasibility and effectiveness of using non-contrast chest computed tomography scans for opportunistic breast cancer screening, and to further compare its diagnostic performance with conventional imaging modalities, including mammography and/or breast magnetic resonance imaging.

Who can participate

Age range18 Years

SexFEMALE

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Inclusion criteria

✓. Female patients who have undergone non-contrast chest CT examination;
✓. Participants included in the comparative analysis must have undergone at least one comparator imaging modality (mammography and/or breast MRI);
✓. If a breast lesion is detected, it must be confirmed by pathology or clinical follow-up at least 12 months;
✓. No prior systemic or local therapy before imaging examinations;
✓. Imaging data are complete and of sufficient quality for analysis.

Exclusion criteria

✕. History of other malignancies with potential impact on breast imaging interpretation;
✕. Participants with suspected malignant breast lesions but no confirmation;
✕. Prior radiotherapy, chemotherapy, or immunotherapy before imaging examinations;
✕. Imaging data that are incomplete, of poor quality, or contain significant artifacts preventing reliable analysis;
✕. Time interval between non-contrast chest CT and comparator imaging modalities exceeding three months, or with clinical events occurring between examinations that may alter lesion status.

What they're measuring

Screening performance of non-contrast chest CT for detection of breast cancer, with comparison to mammography and/or breast MRI

Timeframe: Up to 12 months

Trial details

NCT IDNCT07557654

SponsorFudan University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-05-01

Contact for this trial

Chao You, MD

+86-021-15800780035 youchao@fudan.edu.cn

View on ClinicalTrials.gov More Breast Cancer trials