Not Yet RecruitingNot Applicable

Intestinal Endotoxemia and Beta- Cell Dysfunction in Prediabetics

Egypt120 participantsStarted 2026-05

Plain-language summary

the goal of this observation study is to learn about association between intestinal endotoxemia and prediabetes lean patients with the aim of prevention of diabetes in those category of patients

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: 18-65 years * BMI: 18.5-24.9 kg/m² * ADA prediabetes: FPG 100-125 mg/dL OR 2hPG 140-199 mg/dL OR HbA1c 5.7-6.4% * HOMA-IR \<1.5 (key inclusion criterion) Exclusion Criteria: * \- HOMA-IR ≥1.5 * BMI ≥25 kg/m² * Diabetes, acute inflammation, GI disorders (Table 1) Group II (Controls): Lean normoglycemic ; age and sex-matched healthy subjects

What they're measuring

correlation between intestinal endotoxemia (measured by serum LBP) and basal beta-cell dysfunction (HOMA-B) in lean prediabetic patients

Timeframe: one year

Trial details

NCT IDNCT07557329

SponsorSohag University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-05

Contact for this trial

hanaa mohamed abdel azeem, specialist

+201061139402 hanaaabdelazem161@gmail.com

View on ClinicalTrials.gov More Prediabetic State (IGT) trials