Not Yet RecruitingNot Applicable

Investigating Cognitive Flexibility Training

Singapore225 participantsStarted 2026-04-23

Plain-language summary

The investigators' previous research identified two distinct subtypes of Cognitive Flexibility (CF), termed CF1 (shifting flexibility) and CF2 (strategy flexibility). The present study aims to determine whether these forms of CF can be trained, how they differ, and the extent to which improvements transfer to broader learning and cognitive skills. In addition, social functioning outcomes and the extent to which social factors moderate the effects of cognitive flexibility training are assessed. The investigators will employ a multi-modal approach combining cognitive-behavioural and neuroimaging methods to examine how brain mechanisms and cognitive performance change following CF-targeted training intervention (Structure learning) compared with active control and a no-training paradigm (passive control).

Who can participate

Age range18 Years – 29 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy volunteer (male of female) between 18 and 29 years who gave written informed consent to participate Exclusion Criteria: * Current and/or prior history of learning disabilities * Current and/or prior history of neurological disorder * Current and/or prior history of psychiatric disorder * Current and/or prior history of cardiovascular disorder * Predominantly left-handed * Contraindications for MRI (e.g., pacemakers, implanted pumps, metal objects in the body) * Claustrophobic * Pregnancy (females) * Lactation (females) * Pronounced visual or auditory impairments

What they're measuring

Structure Learning Outcome 1 - Performance Index (PI) Relative

Timeframe: Through training completion (adaptive, up to 12 days)

Structure Learning Outcome 2 - Strategy choice

Timeframe: Through training completion (adaptive, up to 12 days)

Structure Learning Outcome 3 - Strategy ICD index (measured by the integral curve difference)

Timeframe: Through training completion (adaptive, up to 12 days)

Structure Learning Outcome 4 - Learning rate

Timeframe: Through training completion (adaptive, up to 12 days)

Structure Learning Outcome 5 - Strategy shifting rate

Timeframe: Through training completion (adaptive, up to 12 days)

'All You Can E.T.' (AYCET) Outcome 1 - Accuracy

Timeframe: Through training completion (adaptive, up to 12 days)

'All You Can E.T.' (AYCET) Outcome 2 - Response Time (RT)

Timeframe: Through training completion (adaptive, up to 12 days)

Trial details

NCT IDNCT07556250

SponsorNanyang Technological University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-31

Contact for this trial

Kastoori Kalaivanan, PhD

+6569081458 kastoori.k@ntu.edu.sg

View on ClinicalTrials.gov More Healthy trials

Plain-language summary

Who can participate

Age range18 Years – 29 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Structure Learning Outcome 1 - Performance Index (PI) Relative

Timeframe: Through training completion (adaptive, up to 12 days)

Structure Learning Outcome 2 - Strategy choice

Timeframe: Through training completion (adaptive, up to 12 days)

Structure Learning Outcome 3 - Strategy ICD index (measured by the integral curve difference)

Timeframe: Through training completion (adaptive, up to 12 days)

Structure Learning Outcome 4 - Learning rate

Timeframe: Through training completion (adaptive, up to 12 days)

Structure Learning Outcome 5 - Strategy shifting rate

Timeframe: Through training completion (adaptive, up to 12 days)

'All You Can E.T.' (AYCET) Outcome 1 - Accuracy

Timeframe: Through training completion (adaptive, up to 12 days)

'All You Can E.T.' (AYCET) Outcome 2 - Response Time (RT)

Timeframe: Through training completion (adaptive, up to 12 days)