Comparative Study on the Medium- and Long-term Benefits of Prosthesis Selection in Total Knee Art… (NCT07553871) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Comparative Study on the Medium- and Long-term Benefits of Prosthesis Selection in Total Knee Arthroplasty
3,500 participantsStarted 2026-05-31
Plain-language summary
This retrospective real-world study aims to compare the medium- and long-term clinical outcomes, safety, and economic benefits of different knee prosthesis brands used in primary unilateral total knee arthroplasty (TKA) at our hospital. The study will include adult patients who underwent first-time unilateral TKA between January 1, 2022 and December 31, 2025. Outcomes such as postoperative knee function, complications, length of hospital stay, quality of life, and medical costs will be evaluated. The results are expected to provide evidence to support prosthesis selection and optimize healthcare resource allocation.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age \>= 18 years.
* Diagnosis of end-stage knee osteoarthritis, rheumatoid arthritis, or other conditions meeting the indication for TKA.
* First-time unilateral knee arthroplasty.
* Complete medical records, including perioperative records, prosthesis model records, detailed cost information, and regular postoperative follow-up records.
Exclusion Criteria:
* Revision knee arthroplasty, simultaneous bilateral arthroplasty, or concomitant arthroplasty of other joints.
* Arthroplasty performed for non-degenerative conditions such as tumour or acute trauma.
* Perioperative death or loss to follow-up.
* Severely incomplete clinical data that preclude valid analysis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is comparing different knee prosthesis types in total knee replacement — can you explain what the specific implant options being compared are, and which one you would recommend for my particular situation with knee osteoarthritis or rheumatoid arthritis?
2Since this trial isn't recruiting yet, how long might it be before it opens, and would it make sense for me to move forward with a standard knee replacement now rather than waiting?
3The trial's main focus is measuring knee function scores one year after surgery — does that mean the longer-term safety and performance differences between these prostheses are still not well understood, and what do we already know from existing research?
4This study is listed as Phase NA, which I understand may mean it's a comparative observational or registry-style study rather than testing a new treatment — can you explain what that means for how my care might differ from standard treatment if I were to participate?
5Because I have rheumatoid arthritis rather than osteoarthritis, are there specific factors about my condition that would affect which prosthesis is most appropriate for me, and would those factors be taken into account in this trial?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Knee Function Score at 1 Year After Surgery
Timeframe: 1 year after surgery
Trial details
NCT IDNCT07553871
SponsorSecond Affiliated Hospital of Wenzhou Medical University