Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults (NCT07550023) | Clinical Trial Compass
RecruitingNot Applicable
Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults
United Kingdom64 participantsStarted 2026-03-23
Plain-language summary
This study will investigate how adding a specific type of dietary fat to daily meals for two weeks affects the gut bacteria and their activity. Participants will be randomly assigned to consume one of four types of fat: butter, coconut oil, olive oil, or sunflower oil (60 mL each day for 2 weeks). Stool and blood samples (after an overnight fast) will be collected at 3 time points during the study (Days 1, 7, and 22). These samples will be used to measure metabolites produced by gut bacteria, the types of bacteria present in the gut, blood lipids, and inflammatory markers. The study, based on previous in vitro findings, aims to understand whether different types of fats (based on their structure and level of saturation) have different effects on gut bacteria and their activity in healthy subjects.
Who can participate
Age range
20 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 20-50 years
* Body mass index (BMI) between 20 and 30 kg/m²
* Generally healthy
* Stable body weight (±2 kg) over the past 2 months
* Living in the Glasgow area
* Non-smoker
Exclusion Criteria:
* Use of antibiotics within the past 3 months
* Current use of medications affecting gut microbiota or cardiometabolic health
* Regular use of dietary supplements that may influence study outcomes (e.g. probiotics, prebiotics, vitamins, minerals, fish oil), unless willing to discontinue prior to study start
* Presence of chronic gastrointestinal, metabolic, cardiovascular, hepatobiliary, or pancreatic disease
* History of major gastrointestinal surgery
* Diagnosed diabetes or use of lipid-lowering therapy
* Known fat malabsorption disorders
* Pregnant or lactating women
* Post-menopausal women
* Following a restrictive or specific diet (e.g. vegan, ketogenic diet)
* Food allergies or intolerances relevant to study interventions (e.g. dairy, coconut)
* Recent significant weight change (±2 kg in the past month)
* High reliance on ready meals or takeaway foods (\>7 main meals per week)
* Participation in another research study that may interfere with this study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in faecal short-chain fatty acid (SCFA) concentrations
Timeframe: Day 1 (pre run-in), Day 7 (baseline, post run-in), and Day 22 (post-intervention)
2
Change in gut microbiota composition
Timeframe: Day 1 (pre run-in), Day 7 (baseline, post run-in), and Day 22 (post-intervention)