Adjunctive Role of Statin Therapy on Airway Inflammation and Clinical Consequences of Chronic Obstructive Pulmonary Disease

Inclusion Criteria: * Diagnosed Chronic Obstructive Pulmonary Disease per the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria 2025 (post-bronchodilator forced expiratory volume₁/forced vital capacity \< 0.70), meets the definition of grade E Chronic Obstructive Pulmonary Disease by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria 2025 criteria. * Age ≥ 40 years Exclusion Criteria: * Chronic lung diseases other than COPD as bronchial asthma, interstitial lung disease * Acute or chronic Inhalational lung injury. * Established indication for statin therapy (atherosclerotic cardiovascular disease, familial hyperlipidemia). * Chronic debilitating diseases as diabetes mellitus, chronic liver disease, chronic kidney disease, and hematological disorders. * Pregnancy/lactation. * Known hypersensitivity to statins. * Unable or refuse to provide informed consent.