Evaluation of Accelerated Bachmann Bundle Area Pacing in Heart Failure With Reduced ejectIon Frac… (NCT07547306) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Evaluation of Accelerated Bachmann Bundle Area Pacing in Heart Failure With Reduced ejectIon Fraction Who Have electrocarDioGraphic Evidence of Interatrial Block and Indicated for Implantable Cardioverter Defibrillator
120 participantsStarted 2026-05
Plain-language summary
To evaluate the effect of accelerated atrial resynchronization achieved through Bachmann bundle pacing at the time of implantable cardioverter-defibrillator implantation in patients with heart failure with reduced ejection fraction and interatrial block
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age ≥18 years at the time of screening.
✓. A documented diagnosis of chronic heart failure with New York Heart Association (NYHA) class II-IV.
✓. Left ventricular ejection fraction (LVEF) ≤40%, documented by an imaging study performed within 12 months prior to screening.
✓. Receiving optimized guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF), unless contraindicated or not tolerated:
✓. Presence of interatrial block (IAB), defined as a P-wave duration ≥120 ms on a 12-lead electrocardiogram or ECG recording device.
✓. An indication for dual-chamber implantable cardioverter-defibrillator (ICD) implantation for primary or secondary prevention.
✓. NT-proBNP measured within 3 months prior to randomization meeting one of the following criteria:
✕. Acute decompensated heart failure at the time of screening or hospitalization for worsening heart failure within 4 weeks prior to enrollment.
✕. Moderate to severe primary valvular heart disease (functional mitral regurgitation or tricuspid regurgitation is not an exclusion criterion).
What they're measuring
1
Relative change in NT-proBNP at 6 weeks (accelerated Bachmann bundle area pacing ON) compared with baseline (accelerated Bachmann bundle area pacing OFF).